The darkside of anti-inflamatory drugs

Mark Perenich products liability medical negligent lawyer.

Below is an article written by Tim Perenich, he is completing his final year of chiropractic education, and he wanted to share some information about NSAID’s Non-Steroidal Anti-Inflammatory Drugs.  I’m not a physician I do not suggest you discard medical advice, this is only a presentation on the opposing view of the discussion.   If you have a question about your medical treatment, please call your doctor.  If you believe that you or a loved one have been injured as a result of a drug, please contact me ASAP.


 “Take Two and Call me in the Morning…?”


It has almost become cliché in healthcare to treat all minor complaints and even some major ones with aspirin. Society is constantly bombarded with messages through the mainstream media and a pro-drug advertisements that aspirin is safe and effective. And while millions of people take aspirin and other variants like Ibuprophen, Advil, Naproxen etc—AKA Non-Steroidal Anti-Inflammatory Drugs (NSAID’s)—many of them don’t always end up with beneficial outcomes.

For over fifty-years physicians have known NSAID’s cause and exacerbate gastric ulcers (that is erosions or holes in the lining of your stomach and dueodenum).[i] Despite these hazards it is estimated that over 60 million Americans are prescribed NSAIDs per year. The Amercian College of Gasteoenterology reported over “100,000 Americans are hospitalized each year” due to “gasterointestinal bleeding from NSAID use” and approximately 16,500 of them will die.[ii]

However, these are just the statistics of NSAID complications from gastrointestinal bleeding. Some physicians estimate that over all deaths from NSAID complications are between 100,000 to 200,000 in the United States annually.[iii] One of the lesser-known but deadly complications of NSAID use is liver destruction. For example a 39 year old man reportedly taking ibuprophen (an NSAID) at high doses for a tooth ache destroyed his liver, had to be hospitalized, and was put on a waiting list for a liver transplant.[iv] NSAID toxicity can be compounded in the elderly population who are often put on a number of drugs and already have compromised liver function due to age. Another group of people at serious risk for liver damage is alcohol consumers. Taking an aspirin or NSAID following a night of drinking may cause irreversible life-threatening damage to the liver.[v] Alcohol and prescription drug use can deplete the liver of its naturally produced protective antioxidants and hinder its ability to detoxify the blood.

Aside from liver damage NSAIDs have also been implicated in damaging the kidneys, lungs, and the vascular system.[vi] Interestingly, a case leukocytoclastic vasculitis (inflammation of the small blood vessels) was reported right here in Largo, FL following usage of naproxen (another NSAID) resulting in multi-limb amputation for the patient.[vii] Apparently naproxen triggered the immune system to attack the small blood vessels of the body feeding muscles and nerves. This in turn caused damage to the distal limbs producing ischemia making them susceptible to gangrene. The medical staff did all they knew but could not save the limbs.

Though many people have little problem taking something as ubiquitous as Advil (an NSAID) never experiencing any terrible effects, this does not mean these  drugs are safe for everyone. Moreover, just because someone does not experience severe side effects does not mean they are precluded from having subclinical damage to their liver or GI tract. Part of the problem is conventional medicine often overstates the benefits of drugs while understating the risks. *The problem is compounded when patients do not know they have alternatives. *Moreover, many live a lifestyle which makes their condition worse (i.e. smoking, drinking, drug use, and obesity). *While no doctor can force a person to change their lifestyle, they can inform their patients to take control of their well-being. *Thus, the patient can become a wise healthcare consumer. So next time you are told to “take two…” you may think twice.

[i] Muir A, Cossar IA. Aspirin and Ulcer. British Medical Journal. 1955 July 2. 7 – 12.

[ii] American College of Gasteroenterology. Understanding Ulcers, NSAIDs & GI Bleeding. A Consumer Health Guide. (accessed June 9, 2013 at 7

[iii] Prystupa A. NSAID-induced acute liver failure—A Case Report. Baltic Journal of Comparative & Clinical Systems Biology. 2012; 2: 31 – 37.

[iv] Ibid.

[v] Weathermon R, Crabb DW. Alcohol and Medication Interactions. Alcohol Research & Health.1999; 23 (1): 40 – 54.

[vi] Prystupa A. Baltic Journal of Comparative & Clinical Systems Biology. 2012; 2: 31 – 37.

[vii] Brown K, Martin J, Zito S. Severe leukocytoclastic vasculitis secondary to the use of naproxen and requiring amputation: as case report. Journal of Medical Case Reports. 2010; 4: 204.

 Personal injury lawyer clearwater Mark Perenich on drugs and injuries


Finding a Personal Injury lawyer that is right for you

Personal injury lawyer Clearwater Mark Perenich

Is your lawyer right for your case?

Mark Perenich at his clearwater office
Mark Perenich at his Clearwater office
There are several ways to tell if your lawyer is right for you, having an attorney that truly cares about you and your case, and is passionate about representing you is very important especially considering your property, health and future could be in their hands.
Here are a few things to think about when choosing your lawyer:
An ideal lawyer should be caring and compassionate not just have a long list of credentials and impersonal references.  I encourage my clients to come in and meet me, you should meet your personal injury lawyer before hiring them.
Other things to do: identifying no conflicts of interest, understanding everything the retainer agreement states, and checking the references and details regarding the practice.
You will know the lawyer you have chosen is a good choice if:
1. He does the work to understand your case rather than handing it off to an assistant.
2. He can identify what is important and what is not relavent. He will set aside and ignore irrelevant facts, opinions, and personal emotions that cloud the case on hand.
3. All of his work and research is thorough. Accuracy is key in a solid case, facts must be checked several times.
4. He will think outside the box and tackle the problem from every angle.
5. He will use his knowledge to understand the other attoney’s plan of attack as well as the judge’s position in the case.
6. He will not try and confuse you by beating around the bush and using ambiguous statements. He will be clear and concise by explaining everything he needs form you and everything that will happen.
7. He will be practice good work ethic and be courteous to you and his staff.
8. He is recommended by not just his peers and previous clients but by other professionals of good standing and from his field.
9. He will not just boast about cases won but also will be honest why he may have lost certain cases.
10. He will be honest and tell you whether your case stands to win or loose. He will not claim that winning the case is guaranteed. He will be honest and upfront about his opinions and advice.
Do not let your lawyer pursued you by how fancy his car is or how fancy his office is, after all that is not what will help you in court. Your lawyer’s ability to argue the law and respect his/her clients is what is important.
I’ve been practicing injury law for 28 years at Perenich Caulfield Avril Noyes, I cannot guarantee an outcome to anyone, what I can guarantee, however, is that I will fight and work hard for you.

Personal injury lawyer Clearwater Mark Perenich